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Coating Agents in Pharmaceutical Formulations

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Présentation

Coating agents are essential excipients used in pharmaceutical formulations to improve drug stability, control release, and mask unpleasant tastes. These agents form a protective layer around the active ingredient, ensuring optimal drug delivery. This article discusses common coating agents, their properties, and applications.

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Common Coating Agents and Their Functions

Coating agents can be classified based on their solubility, composition, and purpose. Below are some widely used coating materials:

Table 1: Types of Coating Agents and Their Applications

Agent de revêtementFunctionCommon Use Cases
Hydroxypropyl methylcellulose (HPMC)Film-forming, controlled releaseTablets, capsules, sustained-release formulations
Ethyl celluloseInsoluble barrier, taste maskingEnteric coatings, extended-release tablets
ShellacGastric-resistant coatingDelayed-release formulations
Polyvinyl alcohol (PVA)Water-soluble film coatingImmediate-release tablets
Methacrylic acid copolymerspH-dependent releaseEnteric-coated tablets

Selection Criteria for Coating Agents

The choice of a coating agent depends on factors such as drug stability, release profile, and patient compliance. Below is a comparison of key properties:

Table 2: Properties of Common Coating Agents

PropertyHPMCEthyl CelluloseShellacPVAMethacrylic Acid Copolymers
SolubilitéWater-solubleWater-insolublepH-dependentWater-solublepH-dependent
Film FlexibilityHighModerateLowHighModerate
Drug Release MechanismDiffusion-basedDiffusion/erosionpH-triggeredRapid dissolutionpH-triggered
Taste MaskingModerateHighHighLowModerate

Conclusion

Coating agents play a crucial role in pharmaceutical formulations by enhancing drug stability, modifying release profiles, and improving patient acceptability. The selection of an appropriate coating material depends on the desired drug performance and formulation requirements. Understanding the properties and applications of these agents helps in designing effective drug delivery systems.

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