2-Amino-4-Methoxylpyridine - Names and IdentifiersName2-Amino-4-MethoxylpyridineSynonyms4-metho
Courriel : info@standard-groups.com
| Nom | 2 - Amino - 4 - méthoxypyridine |
| Synonymes | 4-methoxypyridin-2-amine 4-METHOXYPYRIDIN-2-AMINE 2-AMINO-4-METHOXYPYRIDINE 2-Amino-4-methoxypyridine 4-Methoxy-2-aMinopyridine 4-Methoxy-2-aminopyridine 2-Amino-4-methoxy pyridine 2-AMINO-4-METHOXYLPYRIDINE 2 - Amino - 4 - méthoxypyridine 4-METHOXY-PYRIDIN-2-YLAMINE 4-Methoxy-Pyridin-2-Ylamine 4-(Methyloxy)-2-pyridinaMine 4-Methoxy-Pyridine-2-ylamine |
| CAS | 10201-73-7 |
| EINECS | 202-713-4 |
| InChI | InChI=1/C6H8N2O/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8) |
| Inchikey | QPHBCOSULYSASF-UHFFFAOYSA-N |
| Formule moléculaire | C6H8N2O |
| Masse molaire | 124.14 |
| Densité | 1.139±0.06 g/cm3(Predicted) |
| Point de fusion | 120-121°C |
| point Boling | 258.6±20.0 °C(Predicted) |
| Point d'éclair | 110.2°C |
| Solubilité dans l'eau | Soluble in Dimethyl sulfoxide, methanol. Slightly soluble in water. |
| Solubilité | DMSO, Methanol |
| pression vapeur | 0.0136mmHg at 25°C |
| Apparence | Crystalline powder |
| Couleur | Pale yellow |
| Maximum wavelength(λmax) | ['280nm(CHCl3)(lit.)'] |
| Le PKA | 7.79±0.11(Predicted) |
| Condition de stockage | Garder dans un endroit sombre, atmosphère inerte, température ambiante |
| Sensible | Sensible à l'air |
| Indice de réfraction | 1.56 |
| MDL | MFCD07437849 |
| Codes de risque | R22 - nocif si avalé R36/37/38 - Irritant pour les yeux, le système respiratoire et la peau. |
| Description de la sécurité | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Wgk Allemagne | 3 |
| Classe de danger | 6.1 |
| Introduction | 2-amino -4-methoxypyridine has a melting point of 120 to 121 degrees, a boiling point of 258.6±20.0 degrees (under one atmospheric pressure), a density of 1.1, and a yellow or yellow-white solid under normal temperature and pressure. It has good solubility in common organic solvents such as dimethyl sulfoxide, N,N-dimethylformamide, ethyl acetate and alcohol solvents, but it has poor solubility in water. |
| Utilisations | 2-amino-4-methoxypyridine is a common organic synthesis intermediate. Its main purpose is to participate in chiral drug molecules as a molecular skeleton, Bioactive molecules and nitrogen-containing ligands in the synthesis. The amino group in its structure can connect the molecular skeleton to the target molecule through acylation reaction under appropriate conditions. In addition, it has been reported in the literature that under suitable reaction conditions, a halogen atom such as bromine and iodine can be introduced in the para position of the amino group. |
| Synthesis method | For the synthesis of 2-amino-4-methoxypyridine, the conventional synthesis method is based on its premise 2-bromo-4-methoxypyridine Starting from, under the promotion of appropriate copper salts, the coupling reaction with nitrogen atoms is carried out to obtain the target product. In addition, there is another synthetic route starting from 2-amino-4-chloro-pyridine. With the help of the electron-deficient nature of the pyridine ring, the target product can also be obtained through the aromatic nucleophilic substitution of sodium methoxide. |
Disclaimer: Le contenu ci-dessus est destiné à des fins de référence et de communication uniquement entre les initiés de l'industrie, et ne garantit pas son exactitude ou son exhaustivité. Conformément aux lois et règlements pertinents et aux règlements de ce site Web, les unités ou personnes qui achètent des articles connexes doivent obtenir des qualifications et des conditions de qualification valides.
Téléphone de l'entreprise
+86-21-6420 0566
Heures de travail
Du lundi au vendredi
Téléphone portable:
13816217984
Courriel :
info@qinsun-lab.com
