2-Hydroxy-5-methylpyridine - Names and IdentifiersName2-Hydroxy-5-methylpyridineSynonymsAKOS BB
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| Nom | 2-Hydroxy-5-methylpyridine |
| Synonymes | AKOS BBS-00002970 5-Methyl-2-pyridinol 6-HYDROXY-3-PICOLINE 5-METHYL-2-PYRIDINOL 5-METHYL-PYRIDIN-2-OL 2-Pyridinol,5-methyl- 5-METHYLPYRIDINE-2-ONE 5-METHYL-2(1H)PYRIDONE 5-methyl-(1H)pyridinone 5-Methyl 2-(1H)pyridinone 5-methylpyridin-2(1H)-one 5-Methyl-2(1H)pypridinone 5-METHYL-2(1H)-PYRIDINONE 5-METHYL-2(1H)PYPRIDINONE 4-methylpyridin-2(1H)-one 5-Methyl-2-(1H)pyridinone 2-Hydroxy-5-methylpyridine 5-Methyl-2-hydroxypyridine |
| CAS | 1003-68-5 91914-06-6 |
| EINECS | 213-713-9 |
| InChI | InChI=1/C6H7NO/c1-5-2-3-7-6(8)4-5/h2-4H,1H3,(H,7,8) |
| Inchikey | SOHMZGMHXUQHGE-UHFFFAOYSA-N |
| Formule moléculaire | C6H7NO |
| Masse molaire | 109.13 |
| Densité | 1.053±0.06 g/cm3(Predicted) |
| Point de fusion | 183-187 °C (lit.) |
| point Boling | 304.2±15.0 °C(Predicted) |
| Point d'éclair | 170.6 °C |
| Solubilité | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pression vapeur | 0 mmHg à 25°C |
| Apparence | White to brown powder or crystal |
| Couleur | Pale Yellow to Light Yellow |
| BRN | 107074 |
| Le PKA | 12.43±0.10(Predicted) |
| Condition de stockage | Scellé à sec, température ambiante |
| Indice de réfraction | 1.551 |
| MDL | MFCD03092888 |
| Propriétés physiques et chimiques |
| Symboles de danger | XN - nocif |
| Codes de risque | R22 - nocif si avalé R37 / 38 - irritation du système respiratoire et de la peau. R41 - Risque de dommages graves aux yeux R36/37/39 - |
| Description de la sécurité | S26 - En cas de contact avec les yeux, rincer immédiatement avec beaucoup d'eau et consulter un médecin. S36 - porter des vêtements de protection appropriés. S37 - Wear suitable gloves. |
| Wgk Allemagne | 3 |
| Code SH | 29333990 |
| Informations chimiques NIST | Informations fournies par : webbook.nist.gov (lien externe) |
| Application | 2-hydroxy-5-methylpyridine is a pharmaceutical intermediate that can be used to prepare pirfenidone. Pirfenidone is a new pyridone compound with broad-spectrum anti-fibrosis effect, which is a white or light yellow crystalline powder. It can prevent and reverse the formation of fibrosis and scars; and the drug also has a good effect in renal interstitial fibrosis, liver fibrosis and other fibrotic diseases; at the same time, it is also used in kidney disease (focal segmental glomerulosclerosis), Hypertrophic cardiomyopathy, adult type I multiple neurofibroma, adolescent type I multiple neurofibroma and plexiform neurofibroma, diabetes with kidney disease, uterine leiomyoma and other phase II clinical studies have a wide range of applications. |
| Préparation | (1) mix 2-amino -5-methylpyridine, diazotization reagent and water evenly, cool to -4 ℃-3 ℃, add acidic solution for heat preservation reaction; After the reaction is complete, heat hydrolysis and cooling, and then adjust the pH to 6.5-7.5 with a mass fraction of 30% sodium hydroxide solution, the organic phase is extracted by the first solvent, dried and concentrated under reduced pressure to obtain 2-hydroxy-5-methylpyridine crude product;(2) A second solvent is added to the 2-hydroxy-5-methylpyridine crude product, heated and refluxed, cooled and crystallizated, pumped and dried to produce 2-hydroxy-5-methylpyridine pure product. |
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