Dapagliflozin is a white crystalline solid that is soluble in water and some organic solvents. It ha
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Dapagliflozin is a white crystalline solid that is soluble in water and some organic solvents. It has a strong odor of rotten eggs. Dapagliflozin is unstable under high temperature and bright light.
Dapagliflozin is mainly used as a pesticide to control various pests, including insects, fungi, and weeds. It can act as an insecticide by blocking the nerve conduction system of pests. Dapagliflozin can also be used as a precursor for explosive substances, such as in the preparation of gunpowder.
The preparation method of dapagliflozin is mainly prepared by methylating nitrourea. Reacting nitroaniline urea with a methylation reagent (such as methine oxide) to obtain N-methylnitroaniline urea. Then, N-methylnitrourea is subjected to nitration reaction, and nitric acid and sulfuric acid are added to nitration it, resulting in the final dapagliflozin product.
-Dapagliflozin is a strong oxidant that should be avoided from contact with flammable materials.
-Maintain good ventilation during operation to avoid inhaling its gas or dust.
-Avoid contact and reaction with strong acids, strong bases, and other substances.
-Dapagliflozin may be toxic to aquatic organisms and should be avoided from being discharged into water sources.
-When using or handling dapagliflozin, appropriate personal protective equipment such as gloves, goggles, and face shields should be worn.
Nom | (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
Synonymes | Daglican BMS-512148 Dapagliflozi BMS-512148-05 Dapagliflozin DAPAGLIFLOZIN DAPAGLIFLOZIN BASE Dapagliflozin propanediol Dapagliflozin S1548 Selleck (1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
CAS | 461432-26-8 |
EINECS | 639-683-0 |
InChI | InChI=1/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1 |
Formule moléculaire | C21H25ClO6 |
Masse molaire | 408.88 |
Densité | 1.349 |
Point de fusion | 55-58°C |
point Boling | 609.0±55.0 °C(Predicted) |
Point d'éclair | 322.139°C |
Solubilité | DMSO : ≥ 100 mg/mL (244.58 mM) |
pression vapeur | 0 mmHg à 25°C |
Apparence | White to off-white (Solid) |
Couleur | White to Pale Yellow |
Le PKA | 13.23±0.70(Predicted) |
Condition de stockage | 2 - 8 degrés Celsius |
Stabilité | Hygroscopique |
Indice de réfraction | 1.614 |
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