pyrazinamide

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Molecular Formula： C5H5N3O

Molecular Weight： 123.1

CAS No.: 98-96-4

It is a drug for the treatment of tuberculosis, which has the effect of antibacterial and bactericidal. Under the condition of pH value of 5 ~ 5.5, the antibacterial activity is the strongest.

Description

It is a white crystalline powder, slightly soluble in water, odorless and slightly bitter.

Application

Combined with other anti tuberculosis drugs, it is used for tuberculosis that has failed to be treated with first-line anti tuberculosis drugs (such as streptomycin, isoniazid, rifampicin and ethambutol). This product is only effective for Mycobacterium. As a second-line drug in the past, this product was often used in retreated patients who failed to be treated with other anti tuberculosis drugs. A large number of clinical studies have shown that the short-term treatment scheme containing this product is suitable for the first treatment cases with positive sputum bacteria, which is generally used for 2 ~ 3 months. This scheme can significantly reduce the positive rate of sputum bacteria after treatment. This product has been recognized as one of the components of triple or quadruple regimens in short-term chemotherapy.

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